breast nodules and thyroid nodules
Conditions
Interventions
Tagilidine fumarate group(Group T):The postoperative analgesic drug is tapentadol fumarate at a dose of 0.01mg/kg.
Hydromorphone group (Group H, positive control group):The postoperative analgesic drug is hydromorphone at a dose of 0.015mg/kg.
Sponsors
Guangzhou Institute of Cancer Research,the Afliated Cancer Hospital, Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1, Aged 18 to 65 years; 2.Patients undergoing modified radical mastectomy, breast-conserving surgery, or partial/total thyroidectomy under tracheal intubation general anesthesia; 3.Apfel simplified risk score (PONV risk score) >= 3 points (i.e., high-risk patients); 4.ASA physical status ?-?; 5.Body mass index (BMI) >= 18 kg/m^2 and <= 30 kg/m^2; 6. Patients voluntarily participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with chronic pain, alcoholism, or drug dependence; 2.Patients taking sedatives, analgesics, or antidepressants before surgery; 3. Patients with allergies to this drug or opioids; 4.Patients with severe preoperative respiratory diseases such as bronchial asthma, COPD, etc.; 5.Patients with other severe preoperative systemic diseases and an ASA physical status of III or higher; 6.Patients with preoperative cognitive impairment, who are expected to have difficulty completing assessments related to outcome indicators; 7.Patients currently participating in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative nausea and vomiting (defined as mild nausea with or without vomitus); | — |
Secondary
| Measure | Time frame |
|---|---|
| QoR-15 score at 24 hours after surgery;po24h NRS score;Perioperative opioid consumption;time to first ambulation;duration of drainage tube indwelling and postoperative hospital stay duration; | — |
Countries
China
Contacts
Public ContactYao Yonghua
Guangzhou Institute of Cancer Research,the Afliated Cancer Hospital, Guangzhou Medical University
Outcome results
None listed