Blood loss during cesarean section
Conditions
Interventions
Ketamine group:After delivery of the fetus and cutting of the umbilical cord, immediately administer an intravenous infusion of 0.20 mg/kg of esketamine.
Dexmedetomidine Group:Immediately after delivery of the fetus and cutting of the umbilical cord, administer an intravenous infusion of 0.2 µg/kg of dexmedetomidine.
control group:After delivery of the fetus and cutting of the umbilical cord, immediately administer the same amount of saline solution at the same rate.
Sponsors
The Third Affiliated Hospital of ZhengZhou University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: (1) American Society of Anesthesiologists (ASA) physical status classification II; (2) Age between 20 and 40 years old; (3) Pregnancy between 37 and 42 weeks; (4) Body mass index (BMI) <= 35 kg/m^2.
Exclusion criteria
Exclusion criteria: (1) Emergency cesarean section; (2) Contraindications for spinal anesthesia (coagulation disorders, lumbar disc herniation, spinal deformities, or history of spinal surgery); (3) Twin pregnancy; (4) Allergy to a2-adrenergic agonists or opioid medications; (5) Preoperative use of analgesics or sedatives; (6) Inability to understand the various scales used in this trial; (7) Neurological or psychiatric disorders; or (8) Enrollment in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of bleeding;Postoperative bleeding volume within 24 hours;Systolic blood pressure/diastolic blood pressure;heart rate;mean arterial pressure;platelet; | — |
Secondary
| Measure | Time frame |
|---|---|
| Restore quality;anxious and depressed state;Postoperative analgesic effect;Hb;white blood cell ;neutrophil;lymphocyte;monocyte;CRP;incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactTao Wang
The Third Affiliated Hospital of ZhengZhou University
Outcome results
None listed