Chronic insomnia disorder
Conditions
Interventions
Bilateral DLPFC group.:Bilateral TBS stimulation at the right dorsolateral prefrontal cortex (DLPFC) (F4 position according to the 10-20 system) and left DLPFC (F3 position according to the 10-20 syst
intertrain frequency 5Hz, 200 trains
stimulation duration 40 seconds, interstimulus interval 8 seconds, 1 repetition, total of 600 pulses), followed by left iTBS (intratrain frequency 50Hz, 3 pulses per train
intertrain frequency 5Hz, 10 trains
stimulation duration 2 seconds, interstimulus interval 8 seconds, 20 repetitions, total of 600 pulses). After a 15-minute interval, the above procedure is repeated, with alternating TBS stimulation of
Right DLPFC group : Bilateral TBS stimulation at the right dorsolateral prefrontal cortex (DLPFC) (F4 position according to the 10-20 system) at an intensity of 70% RMT. The right side is subjected to
stimulation duration 40 seconds, interstimulus interval 8 seconds, 1 repetition, total of 600 pulses). After a 15-minute interval, the above procedure is repeated, with TBS stimulation of the right DL
Sham stimulation group.:The sham stimulation coil has the same shape and sound as the real stimulation coil, but does not emit a magnetic field. The sham stimulation protocol is randomly selected from
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnostic criteria for chronic insomnia disorder as defined in the International Classification of Sleep Disorders, Third Edition (ICSD-3); (2) Pittsburgh Sleep Quality Index (PSQI) score>= 8, Insomnia Severity Index (ISI) score >= 10; (3) Stable vital signs, no severe aphasia, visual, auditory, or cognitive impairments, able to cooperate in completing the study protocol; (4) Aged 18-65 years, right-handed; (5) Voluntarily participate and sign the informed consent form, or consent may be waived.
Exclusion criteria
Exclusion criteria: (1) A history of rTMS, transcranial electrical stimulation (tES), or other treatments in the past month; (2) A history of brain organic diseases, brain injury, stroke, severe mental disorders, craniotomy, or cranioplasty; (3) Implantation of metallic or electronic devices (e.g., pacemakers, cochlear implants, deep brain stimulators, aneurysm clips, internal fixation devices after ventriculoperitoneal shunt surgery, etc.); (4) A history of substance abuse (caffeine, nicotine, and alcohol); (5) Severe aphasia that prevents the completion of the assessment; (6) Other serious diseases that may affect the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pittsburgh Sleep Quality Index;Digit Span Test;n-back; | — |
Secondary
| Measure | Time frame |
|---|---|
| Insomnia Severity Index;Epworth Sleepiness Scale;Self-Rating Anxiety Scale;Hamilton Anxiety Scale;Self-Rating Depression Scale;Hamilton Depression Rating Scale;Rivermead Behavioural Memory Test;Functional Near-Infrared Spectroscopy;Activity Monitor; | — |
Countries
China
Contacts
Public ContactZhang Liying
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed