Tracheal intubation stress response
Conditions
Interventions
Experimental group:According to the BCD method, different doses of alfentanil will be used to suppress the response to tracheal intubation. It is expected that there will be 6 groups, with doses of 5
Sponsors
Zhongshan Hospital (Xiamen Branch), Fudan University, Xiamen
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age 18–65 years, BMI >= 30 kg/m²; (2) ASA (American Society of Anesthesiologists,ASA) physical status classification I–III; (3) Willing to participate and sign the informed consent form; (4) Elective surgery.
Exclusion criteria
Exclusion criteria: (1) History of allergy to opioid drugs or severe allergy to other medications; (2) History of opioid abuse, long-term use of psychotropic drugs, or participation in other drug trials within the past year; (3) Decompensated liver or kidney function; (4) Patients who failed intubation within 1 minute or required a second intubation attempt; (5) Patients undergoing surgery involving the upper respiratory tract or lungs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate;Blood pressure; | — |
Countries
China
Contacts
Public ContactLiu Jie
Zhongshan Hospital (Xiamen Branch), Fudan University, Xiamen
Outcome results
None listed