Alzheimer's Disease
Conditions
Interventions
Deep cervical lymphaticovenular anastomosis in the AD group:None
Sponsors
Zhengzhou Central Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1.Meet the diagnostic criteria for AD (2018 NIA-AA diagnostic criteria), severe AD patient CDR-SB > 16; 2.AD patients who have received dcLVA surgical treatment; 3.Have complete neuropsychological assessments, physical examinations, cranial MRI medical records; 4.Research subjects have stable and reliable caregivers, or at least frequent contact with caregivers (at least 4 days per week, at least 2 hours per day); 5.Individuals or their families voluntarily participate in this study, provide biological samples, and sign informed consent forms;
Exclusion criteria
Exclusion criteria: 1.Existence of severe mental illness (diagnosed or requiring medication-controlled schizophrenia, bipolar affective disorder, mental retardation, etc.); 2.Existence of other causes leading to dementia, including vascular dementia, central nervous system infections (such as viral encephalitis, tuberculous meningitis, syphilis, etc.), concurrent with other neurodegenerative diseases (such as Parkinson’s disease, multiple system atrophy, Lewy body dementia, frontotemporal dementia, Creutzfeldt-Jakob disease, Huntington’s disease, etc.), traumatic dementia, other physical and chemical factors (such as drug poisoning, alcoholism, carbon monoxide poisoning), endocrine imbalance (such as thyroid disease, parathyroid disease), and other factors (vitamin deficiency, epilepsy, etc.) leading to dementia; 3.Patients already diagnosed with malignant tumors, organ dysfunction;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Score on the Clinical Dementia Rating-Sum of Boxes (CDR-SB); | — |
Secondary
| Measure | Time frame |
|---|---|
| Cerebrospinal fluid biochemical indicators;Score on the 14-item cognitive subscale of the Alzheimer's Disease Assessment Scale;Biochemical blood indicators;the change in amyloid burden on PET;Score on the Alzheimer's Disease Cooperative Study-Activities of Daily Living Scale for Mild Cognitive Impairment;Alzheimer's Disease Composite Score; | — |
Countries
China
Contacts
Public ContactJianping Ye
Zhengzhou Central Hospital
Outcome results
None listed