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Protecting Memory After Surgery: Can Pain Prevention and Nasal Insulin Help Older Adults with Broken Bones

A prospective, randomized, single-blind clinical study: Preemptive analgesia combined with preoperative transnasal insulin therapy reduces postoperative delirium in elderly patients undergoing lower extremity fracture surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500107540
Enrollment
Unknown
Registered
2025-08-13
Start date
2023-03-31
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, cognitive function

Interventions

Hyperalgesia Group:hyperalgesia
Control group:None
Intranasal insulin Group:Transnasal insulin therapy
Hyperalgesia + Intranasal insulin group:Pre-operative treatment with nerve block hyperalgesia combined with transnasal administration of regular insulin

Sponsors

Hebei Medical University Third Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 80 Years

Inclusion criteria

Inclusion criteria: Elderly patients with ASA class II-III, aged 65-80 years, undergoing elective lower extremity fracture repair with an expected duration of 1 hour or more. Patients participated voluntarily and signed an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Patients with a history of neuropsychiatric disease; 2. History of long-term use of psychotropic drugs, chronic analgesics, corticosteroids, etc., or history of alcohol abuse; 3. Preoperative cognitive dysfunction pre-existing, preoperative Mini-Intelligence Scale (MMSE) score < 24 points; 4. Patients with hearing and vision impairment; 5. Liver and kidney insufficiency; 6. Emergency surgery and secondary surgery; 7. Patients who cannot accept general anesthesia or are allergic to anesthetic drugs.

Design outcomes

Primary

MeasureTime frame
postoperative delirium(POD);—

Secondary

MeasureTime frame
Insulin Resistance Index(IR);Matrix metalloproteinase-9(MMP-9);p-tau;cognitive level;insulin;Sleep Quality Score(SRSS);IL-6;Pain simulation Score;S100ß;Montreal Cognitive Assessment(MoCA);TNF-a;—

Countries

China

Contacts

Public ContactPeng Liu

Hebei Medical University Third Hospital

liupeng2016@hebmu.edu.cn+86 311 8860 2072

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026