Gallbladder stones
Conditions
Interventions
The control group (group C):Saline (medicine)
The glycopyrrolate group(group G):Group G was injected with 4 µg/kg of glycopyrrolate intravenously,
Penehyclidine hydrochloride group (group P):Penehyclidine hydrochloride
Sponsors
The First People’s Hospital of Jingzhou
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1.Sex is not limited, age 18~64 years old; 2.ASA classification: Grade I-II, no airway obstruction; 3.BMI=18~30 kg/m2; 4.Patients undergoing elective laparoscopic cholecystectomy; 5.Complete and accurate clinical information. 6.No significant cardiac, pulmonary, hepatic, renal or other vital organ dysfunction; 7.The patients and their families were fully aware of the process of this study and were willing to sign the informed consent and follow the order strictly as required.
Exclusion criteria
Exclusion criteria: 1. Unconsciousness or cognitive impairment; 2. Allergy to anticholinergic drugs and their constituents; 3. Poorly controlled hypertension (SBP > 160 mmHg or DBP >100 mmHg); 4. Patients with atrioventricular block, bradycardia, severe arrhythmia and unstable angina pectoris; 5. Patients with glaucoma; 6. Unconsciousness or cognitive impairment; 7. History of postoperative nausea, vomiting and motion sickness; 8. Pregnancy or lactation; 9. Participated in other drug clinical trials within the past 3 months; 10. Patients who refused to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of nausea and vomiting 24h after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| HR and MAP;Oral glandular secretion, length of stay in the PACU;Dry mouth (xerostomia), delirium, urinary retention, and time to first venting;Hypotension, bradycardia;Incidence of nausea and vomiting at 1 h postoperatively.; | — |
Countries
China
Contacts
Public ContactRui Xia
The First People’s Hospital of Jingzhou
Outcome results
None listed