Traumatic brain injury
Conditions
Interventions
Gold Standard:Head CT
Index test:After centrifugation of whole blood samples, serum was collected for detection of NSE, GFAP, S100B, Tau, MBP (myelin basic protein), NFL, IL-6, IL-8, IL-10, IL-1 ß, TNF - a, UCH-L1, P-Tau,
Detection of NSE in cerebrospinal fluid samples GFAPTauNFL Blood brain barrier index (cerebrospinal fluid albumin/serum albumin), etc. The remaining specimens were frozen at -80 ° C in a refrigerator
Sponsors
The First Affiliated Hospital of PLA Air Force Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 80 cases of traumatic brain injury group, inclusion criteria: 1. The age range is 18 to 65 years old. 2. According to the Glasgow Coma Scale (GCS) score, patients with mild traumatic brain injury score 13-15 points, patients with moderate traumatic brain injury score 9-12 points, and patients with severe traumatic brain injury score 3-8 points. 3. Injury time: Within 24 hours of acute traumatic brain injury. 4. No other system damage. 5. First visit and hospitalization after injury. 80 cases of fracture control group,inclusion criteria for: 1. Age: 18-65 years old; 2. Injury time: Patients with simple limb or spinal fractures within 24 hours; 3. No other system damage; 4. First visit and hospitalization after injury
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1.History of neurological or psychiatric disorders; 2. Prior to this injury, there was a traumatic brain injury; 3.History of alcohol or drug abuse; 4. Complications caused by mild traumatic brain injury combined with other injuries (systemic trauma, facial trauma, or spinal cord trauma) or other reasons (psychological trauma, language disorders); 5.Patients who are lost during treatment and have incomplete information.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NSE;glial fibrillary acidic protein;S100 Calcium-Binding Protein B;Microtubule-Associated Protein Tau;Myelin Basic Protein;Neurofilament Light Chain;Interleukin 6;Interleukin 8;Interleukin 10;Interleukin 1ß;Tumor Necrosis Factor Alpha;Ubiquitin Carboxyl-Terminal Hydrolase L1;Phosphorylated neuronal microtubule-associated protein;Brain-Derived Neurotrophic Factor;Vascular Endothelial Growth Factor; | — |
Countries
China
Contacts
Public ContactJunjie Li
The First Affiliated Hospital of PLA Air Force Military Medical University
Outcome results
None listed