Facial Acne Atrophic Scars or Facial Skin Photoaging
Conditions
Interventions
Observation:Light-conducting gel without active ingredients
Observation Group:Dr.YU skin barrier recovery cream
Sponsors
the first hospital of hebei medical university
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1.Subjects must be between 18 and 45 years old (inclusive) at the time of screening, with no gender restrictions. 2.Subjects must meet the diagnostic criteria for facial acne atrophic scars or facial skin photoaging, with lesions roughly symmetrically distributed, no accompanying acute facial erythema or allergic symptoms, willingness to undergo treatment, and suitability for CO2 fractional laser treatment as determined by the study physician. 3.The physiological parameter of skin barrier function on the cheeks, specifically the stratum corneum hydration (SCH), must be less than 40. 4.Subjects must be able to communicate effectively with the researchers, provide informed consent prior to the study, voluntarily sign a written informed consent form, and agree to comply with all study procedures.
Exclusion criteria
Exclusion criteria: 1.Pregnant or breastfeeding women, or women planning to become pregnant during the study period. 2.Patients with severe systemic diseases such as hypertension, heart disease, diabetes, autoimmune diseases, hematological disorders, chronic severe infections, psychiatric disorders, or malignant tumors. 3.Individuals with a history of keloids, severe skin allergies, photosensitivity, or hypersensitivity; or those allergic to any known components of the intervention product. 4.Presence of other facial skin diseases, active herpes simplex, active skin infections, or open wounds on the face. 5.Individuals with any contraindications to CO2 fractional laser treatment. 6.ndividuals who have undergone other facial cosmetic treatments (including but not limited to phototherapy, injection treatments, chemical peels, etc.) or used topical medications such as retinoids or glucocorticoids that may affect study results within four weeks prior to screening. 7.Individuals who have systemically used glucocorticoids, immunosuppressants, isotretinoin, photosensitizing drugs, or other medications that may affect study results within 12 weeks prior to screening. 8.Other individuals deemed unsuitable for participation in this clinical study as evaluated by the study physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Facial Image Analysis;Transepidermal water loss, TEWL;Skin Surface pH;Stratum corneum hydration, SCH; | — |
Secondary
| Measure | Time frame |
|---|---|
| Subject Self-Assessment;Researcher Visual Assessment; | — |
Countries
China
Contacts
Public ContactZhang Guoqiang
the first hospital of hebei medical university
Outcome results
None listed