Nasopharyngeal carcinoma
Conditions
Interventions
Gold Standard:Electronic nasopharyngoscopy with or without pathological biopsy Follow-up follow-up: By simultaneously performing serum VCA-IgA combined EBNA1-IgA dual antibody screening, P85 antibody
Index test:1. Serum VCA-IgA combined with EBNA1-IgA dual antibody screening 2. P85 antibody screening 3. EBV DNA screening 4. Sequential screening two-step method, referred to as the two-step method:
Sponsors
Fifth Affiliated Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
30 Years to 69 Years
Inclusion criteria
Inclusion criteria: 1.Voluntarily signed informed consent. 2.Age between 30 and 69 years at the time of screening. 3.Residents of Guangdong Province or Guangxi Province. 4.Able to cooperate with long-term follow-up.
Exclusion criteria
Exclusion criteria: 1.Severe medical comorbidities, significant organ (heart, lung, liver, kidney) dysfunction, or psychiatric disorders. 2.Severe autoimmune diseases or immunodeficiency. 3.History of or current malignant tumors. 4.Inability to cooperate with the study due to psychological, social, familial, or geographical reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity;Positive predictive value (PPV); | — |
Secondary
| Measure | Time frame |
|---|---|
| Negative predictive value;Nasopharyngeal Carcinoma Death Rates;Early diagnosis rate of nasopharyngeal carcinoma; | — |
Countries
China
Contacts
Public ContactChen Mingyuan
Fifth Affiliated Hospital, Sun Yat-Sen University
Outcome results
None listed