Diabetes
Conditions
Interventions
Highly resistant starch group:Special wheat flour bread rolls for consumption with high resistant starch
Control group:Regular wheat flour group meal kit
Sponsors
Luoyang Central Hospital Affiliated to Zhengzhou University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Meet the 1999 WHO criteria for the diagnosis and treatment of type 2 diabetes; 2. The course of the disease does not exceed 5 years; 3. Body mass index (BMI)>= 24 kg/m^2; 4. Age 18-70 years old; 5. Glycated hemoglobin >=6.5%.
Exclusion criteria
Exclusion criteria: 1. Exclude type 1 diabetes mellitus and special types of diabetes; 2. Patients who have received hypoglycemic drugs such as thiazolidinediones, GIP/GLP-1RA, glycosidase inhibitors or DPP-IV enzyme inhibitors, GKA and other hypoglycemic drugs within 2 weeks before enrollment; 3. Those who use antibiotics or probiotic supplements within 3 months before enrollment or in the study; 4. Acute and chronic digestive system diseases or related drugs (including diarrhea, gastrointestinal infection, cholecystitis, digestive tract obstruction, etc.); gastrectomy, fundoplication, colostomy and other digestive system surgery; 5. Weight fluctuations in the past 3 months>5%; Suffering from diseases that may affect absorption, metabolism and body weight (such as Cushing, hyperthyroidism, hypothyroidism, etc.); 6. Patients with moderate or severe renal impairment (serum creatinine >2mg/dL or 177mmol/L), or abnormal liver function (ALT>2 times the upper limit of normal); moderate and severe chronic obstructive pulmonary disease; patients with severe hypertension, cerebrovascular accidents and tumors; 7. Those with a history of severe drug allergy, asthma, urticaria or other allergies; 8. Pregnant and lactating women; 9. Those who suffer from active infectious diseases such as tuberculosis, hepatitis and AIDS; 10. Patients with severe and acute complications of diabetes, such as: diabetic ketoacidosis, lactic acidosis, diabetic hyperosmolar state, diabetic foot, severe chronic complications, etc.; 11. Subjects receiving controlled medications, including antidepressants, antiserotonin, barbiturates, antipsychotics, central nervous system stimulants; 12. Those who have poor compliance or difficulty in completing treatment; 13. Unable to guarantee sufficient time to participate in this project; 14. Other researchers are not suitable to participate in this project after evaluation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time spent within target blood glucose range before and after intervention; | — |
Secondary
| Measure | Time frame |
|---|---|
| Glucose tolerance test;Blood lipids;Short-chain fatty acids;Weight;Body composition analysis; | — |
Countries
China
Contacts
Public ContactYanfang Zhang
Luoyang Central Hospital Affiliated to Zhengzhou University
Outcome results
None listed