Total knee arthroplasty
Conditions
Interventions
Part One:The possible doses of hydromorphone around the nerve are as follows: 6-8-10-15-20-25-30-35-40 ug/ml. The initial dose is 10 ug/ml. Subsequently, the patients dose is adjusted using the biased
Part two: hydromorphone combined with ropivacaine group: Continuous caudal block analgesia was administered with 0.25% ropivacaine and ED90 µg/ml hydromorphone, with a total dose of 300 ml. The infusi
Part two: ropivacaine group:Continuous caudal block analgesia was administered with 0.25% ropivacaine, with a total dose of 300ml. The infusion rate was maintained at 4ml/h, the bolus dose was 5ml/ml,
Sponsors
Peking University Shougang Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. ASA classification of I-III; 2. BMI 18-35kg/m^2; 3. Aged 18-80 years; 4. Patients undergoing unilateral total knee arthroplasty under spinal anesthesia and receiving postoperative analgesia; 5. Patients voluntarily participating in the trial, with informed consent signed by the patient one day before surgery
Exclusion criteria
Exclusion criteria: 1. Patients who do not agree or voluntarily withdraw from the study; 2. Patients with a history of knee joint trauma, surgery, malignant tumor, or primary disease of the lower limb nerves or muscles; 3. Patients with severe underlying diseases, such as dysfunction of organs like the heart, liver, lungs, kidneys, and brain, and abnormal blood coagulation; 4. Patients with a history of mental illness; 5. Patients with cognitive impairment who cannot complete analgesia scoring; 6. Patients with contraindications to spinal anesthesia;7. Patients who are allergic to any of the drugs used in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The active NRS score 24 hours after the operation;Postoperative resting NRS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative opioid consumption;Postoperative opioid-related adverse reactions;Postoperative knee joint function score; | — |
Countries
China
Contacts
Public ContactGuo Zhenggang
Peking University Shougang Hospital
Outcome results
None listed