Cognitive dysfunction (CD)
Conditions
Interventions
Grouped according to UACR value: UACRUACR>=30mg/g UACR>=300mg/g:No intervention
Sponsors
Jing'an District Central Hospital Of Shanghai
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Adults aged 60 years and older who are outpatient or inpatient; 2.No history of use of various microecological preparations and antibacterial drugs within 1 month; 3.No history of eating foods containing lactic acid bacteria (such as yogurt, cheese, kimchi, etc.) within 1 week; 4.Ability to cooperate with cognitive assessment without a definitive diagnosis of cognitive impairment; 5.Signed informed consent;
Exclusion criteria
Exclusion criteria: 1.History of previous gastrointestinal surgery or active gastrointestinal infection (of which appendicitis will not be enrolled within 1 year after surgery); 2.Patients with severe mental illness or vision, hearing and speech disorders, severe cardiovascular and cerebrovascular diseases, malignant tumors, confusion, etc. that may affect the study results and cognitive assessment; 3.Patients with anticholinergic drugs, benzodiazepines, chemotherapy drugs, etc. that affect the assessment of cognitive impairment; 4.Underwent anesthesia surgery in the last 6 months; 5.Suspected patient with moderate to severe cognitive impairment and no guardian/surrogate or guardian/surrogate refusal to sign;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| urine microalbumin/urine creatinine ratio;Cognitive Function Assessment Scale score (GPCOG, CDR);16S rRNA sequencing was used to evaluate the diversity and composition of intestinal flora; | — |
Countries
China
Contacts
Public ContactYi Yang
Jing'an District Central Hospital Of Shanghai
Outcome results
None listed