depression, anxiety, lack of pleasure, etc
Conditions
Interventions
TI active stimulation group (2mA):TI active stimulation (2mA)
TI active stimulation group (15mA):TI active stimulation (15mA)
TI pseudo stimulus group:TI pseudo stimulus
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years; 2. Meeting the diagnostic criteria for depression in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5); 3. Total score of Hamilton Depression Rating Scale-24 (HAMD-24) >= 20; 4. Right-handed; 5. Normal results in physical examination, medical history, vital signs, routine blood/urine/stool tests, liver and kidney function, electrolytes, electrocardiogram (ECG), electroencephalogram (EEG), and other indicators; 6. Willing to actively cooperate with treatment after fully understanding the safety of transcranial temporal interference stimulation (tTIS), and signing the informed consent form along with their family members.
Exclusion criteria
Exclusion criteria: 1. Aged 65 years; 2. Having a history of severe physical diseases, or depression caused by other psychoactive substances and non-dependent substances; 3. Having metal or electronic devices implanted in the body, such as intracranial metal foreign bodies, cochlear implants, cardiac pacemakers, stents, or other metal foreign bodies; 4. At risk of epileptic seizures, with a history of craniocerebral diseases, head trauma, alcoholism, abnormal electroencephalogram (EEG), MRI evidence of abnormal brain structure, or a family history of epilepsy; 5. Having psychotic symptoms that require combined use of antipsychotic drugs; 6. Having received electroconvulsive therapy (ECT) or other physical therapies within 2 months before enrollment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptoms such as anxiety, suicide, sleep issues, and anhedonia;Depressive symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasticity indicators such as brain region activation and functional connectivity;Working memory, impulse inhibition ability, etc; | — |
Countries
China
Contacts
Public ContactDongsheng Zhou
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed