Cardiovascular and Cerebrovascular Diseases
Conditions
Interventions
Cardiovascular and Cerebrovascular Disease Group:None
Healthy Control Group:None
Sponsors
Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Cardiovascular and Cerebrovascular Disease Group (1)Patients diagnosed with cardiovascular and cerebrovascular diseases in our hospital after June 2024 mainly include those with coronary atherosclerotic heart disease, essential hypertension, prehypertension, ischemic stroke, and cardiovascular metabolic comorbidities, etc. (2) Age >=18 years old; (3) The overall condition of the patient can undergo all examinations and follow-ups. (4) Participate voluntarily and sign the informed consent form. 2. Healthy control group Healthy volunteers who visited or were recruited at our hospital's physical examination center, whose age and gender composition matched those of the case group, were excluded from medical histories of hypertension, coronary heart disease, stroke, chronic kidney disease, thyroid dysfunction, malignant tumors, etc. (2) Age >=18 years old; (3) The overall condition of the patient can undergo all examinations and follow-ups. (4) Participate voluntarily and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Suffering from severe eye diseases such as age-related macular degeneration, macular edema, glaucoma, and proliferative diabetic retinopathy; 2. Previous history of retinal and choroidal surgery; 3. Coexisting with other systemic diseases (such as liver and kidney dysfunction, malignant tumors, thyroid dysfunction, autoimmune diseases, etc.); 4. Severe neurological diseases or cognitive dysfunction (such as Alzheimer's disease, Parkinson's disease, etc.). 5. Individuals from vulnerable groups such as pregnant and postpartum women, the elderly (aged 75 and above), and those with mental illnesses.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ocular examination parameters (visual acuity, intraocular pressure, fundus color photography, OCT, OCTA).;General clinical parameters: gender, age, body mass index, education level, history of systemic and ocular diseases, etc.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiovascular disease-related physical examination (blood pressure, heart rate, pulse oximetry, etc., on the day of enrollment).;Blood tests: Complete blood count, liver and kidney function, electrolytes, blood lipids, cardiac enzymes, C-reactive protein, troponin, NT-ProBNP; glucose metabolism-related tests (glycated hemoglobin, glycated albumin, etc.);Cardiac-related tests: Echocardiography, bilateral carotid artery Doppler ultrasound, electrocardiogram; coronary angiography-related data: degree of coronary artery stenosis and severity of lesions scoring.;Cerebral examinations: Contrast-enhanced MRI of the head and neck; contrast-enhanced CT of the head and neck, carotid artery Doppler ultrasound, cerebral angiography, etc.;The follow-up content includes the patient's readmission status, occurrence of hypertension, cardiovascular and cerebrovascular adverse events, recurrence of cardiovascular and cerebrovascular adverse events (such as chest tightness, angina, etc.), and occurrence of endpoint events (death, fatal or non-fatal myocardial infarction, fatal or non-fatal stroke, revascularization, hospitalization due to heart failure). Detailed information regarding the patient's diagnosis and treatment, including on; | — |
Countries
China
Contacts
Public ContactXiaohong Yang
Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences)
Outcome results
None listed