Diagnostic Value of Cerebrospinal Fluid Heparin-Binding Protein for Central Nervous System Infections after Neurosurgery

Diagnostic Value of Cerebro-Spinal Fluid Heparin-Binding Protein for Central Nervous System Infections after Neurosurgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2500107425

Enrollment

Unknown

Registered

2025-08-11

Start date

2025-08-11

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Central Nervous System Infections after Neurosurgery

Interventions

Gold Standard:Positive microbial culture of drainage tube head, implant, tissue and cerebrospinal fluid should be excluded from bacterial contamination and colonization.

Index test:Heparin-binding protein in cerebrospinal fluid

Eligibility

Sex/Gender

All

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1 Age >= 18 years; 2 Scheduled for elective craniotomy; 3 Requiring postoperative ventricular drain or scheduled ventricular/lumbar puncture for cerebrospinal fluid (CSF) sampling; 4 Provision of signed informed consent

Exclusion criteria

Exclusion criteria: 1 Diagnosed with active infection within 6 months (including pneumonia, central nervous system infection, etc.); 2 Immunosuppressed status (e.g., use of immunosuppressant medications, chemotherapy); 3 Comorbid hematologic disorders, diabetes mellitus, or organ failure.

Design outcomes

Primary

Measure	Time frame
Heparin-Binding Protein;CSF culture;Accuracy;Sensitivity;Specificity;	—

Countries

China

Contacts

Public ContactYANG CAIE

Sanbo Brain Hospital , Capital Medical University

research1212@163.com+86 136 2130 6733

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026