Alzheimers disease
Conditions
Interventions
Sponsors
Panzhihua Central Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: Participants include cognitively unimpaired (CU) individuals, patients with mild cognitive impairment (MCI), and those with Alzheimer's disease (AD), aged 50 to 85 years, with a BMI between 18.5-30 kg/m². Their serum vitamin D levels cover the full range of sufficiency (=30 ng/mL), insufficiency (20-29 ng/mL), and deficiency (<20 ng/mL).
Exclusion criteria
Exclusion criteria: 1. Confounding diseases: Patients with complicated severe liver or kidney diseases, other neurodegenerative diseases (such as Parkinson's disease), systemic inflammatory diseases, or metabolic diseases (uncontrolled diabetes (HbA1c > 7.5%), abnormal thyroid function (TSH beyond 0.5-5.0 mIU/L)). 2. Drug interference: Patients who have used vitamin D supplements recently (within 3 months), long-term users of immunosuppressants/anti-inflammatory drugs; those using cholinesterase inhibitors or memantine must have maintained a stable dose for = 3 months. 3. Data quality: Patients with motion artifacts in PET scans, or those with hemolyzed plasma samples or samples subjected to repeated freezing and thawing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vitamin D;Aß PET/CT;tau PET/CT; | — |
Secondary
| Measure | Time frame |
|---|---|
| APOE e4;ptau217;Aß42/40 Ratio; | — |
Countries
China
Contacts
Public ContactSun Jiangming
Panzhihua Central Hospital
Outcome results
None listed