amygdalitis
Conditions
Interventions
Sequential test group:The first part: to determine the optimal nasal compatible dose of esmketamine and dexmedetomidine by modified Dixon sequential method
Control group:Intranasal drip of dexmedetomidine 3 µ g/kg
Observation group:Intranasal drip of dexmedetomidine 2 µ G/kg, and 95% of Esketamine ED
Sponsors
Huzhou First People's Hospital
Eligibility
Sex/Gender
All
Age
3 Years to 7 Years
Inclusion criteria
Inclusion criteria: ASA grade I to II; Tonsillectomy was performed in our hospital; Age 3~7 years old, weight 10~30 kg (BMI 13~24 kg/m^2); ECG showed no abnormality and atropine test was negative; There was no anemia and metabolic disorder (including water, electrolyte, acid-base balance disorder) before operation;
Exclusion criteria
Exclusion criteria: History of systemic diseases (congenital heart disease, asthma or central nervous system disease, etc.), abnormal liver and kidney function, drug or food allergy history, abnormal nasal structure; Have a history of upper respiratory tract infection in the past two weeks and have used Dex, etc. one month before operation a 2 Receptor agonists and other drugs that affect the test results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure;SpO2;heart rate;Wisconsin children's Hospital sedation scale score,CHW??;Awakening time;PACU dwell time;pediatric anesthesia emergence delirium,PAED;FUNK neurobehavioral score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Operation time;Postoperative adverse reactions;Face, legs, activity, cry, consolability,FLACC; | — |
Countries
China
Contacts
Public ContactMao Weiliang
Huzhou First People's Hospital
Outcome results
None listed