Severe Traumatic Brain Injury
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 18~65 years old; 2. Meet the diagnostic criteria for severe head trauma; the time from injury to admission does not exceed 24 hours; 3. Intracranial lesions confirmed by head CT examination; 4. The expected ICU stay time is not less than 72 hours; 5. The patient's family signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Previous history of head trauma or neurological disease; 2. Combined with malignant tumors or hematological diseases; 3. Pregnant or lactating women; 4. Previous history of mental illness or cognitive dysfunction; 5. Cardiac and respiratory arrest or expected survival time less than 72 hours before admission; 6. Participate in other clinical trials at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intracranial pressure dynamic changes;Neurological function changes (GCS score);Early complication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| ICU length of stay;Total length of stay;Mechanical ventilation time;28-day all-cause mortality;Functional Independence Measure (FIM) score;Return to work/study status;Short Form 36 Health Survey (SF-36) score; | — |
Countries
China
Contacts
The First Affiliated Hospital of Xinxiang Medical University