Oral cancer and oropharyngeal cancer
Conditions
Interventions
Gold Standard:The clinical diagnosis of oral and oropharyngeal cancer relies on traditional pathology examinations, particularly through pathological slides stained with Hematoxylin and Eosin (H&E) an
Index test:An artificial intelligence-based standardized pathological report intelligent diagnostic system
An HPV infection status prediction model for oropharyngeal cancer
An immune therapy companion
Sponsors
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with squamous cell carcinoma originating from the oral and maxillofacial head and neck after diagnosis and treatment in our hospital; 2. Diagnosis age greater than 18 years old; 3. Have complete pathological H&E sections and embedded wax blocks; 4. Tumor pathological diagnosis according to the WHO Histology Code: 8070-8076 and 8078; The tumor onset site conforms to ICD-O-3 anatomical codes (Topography Codes): oral cavity and oropharynx; 5. Have complete molecular diagnostic results such as IHC-P16, HPV16/18 RNA CISH, IHC-PD-L1, etc.; 6. Receiving one or more methods of surgery, radiotherapy, chemotherapy or targeted therapy in our hospital; 7. Have complete and statistical clinical hospitalization records or diagnosis and treatment data.
Exclusion criteria
Exclusion criteria: 1.History of other malignant tumors or concurrent malignant tumors; 2.Cases where typical epithelial areas and tumor areas cannot be marked; 3.Pathological slide images are unclear or the slides are damaged;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity;Diagnostic Accuracy of AI System;Area Under ROC Curve; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cohen's Kappa Agreement;Intraclass Correlation Coefficient; | — |
Countries
China
Contacts
Public ContactLi Jiang
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Outcome results
None listed