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A Near-Infrared Spectroscopy Investigation of the Mechanisms Underlying Prefrontal Activation and Functional Connectivity Modulation by Transcranial Direct Current Stimulation (tDCS) in Generalized Anxiety Disorder

A Near-Infrared Spectroscopy Investigation of the Mechanisms Underlying Prefrontal Activation and Functional Connectivity Modulation by Transcranial Direct Current Stimulation (tDCS) in Generalized Anxiety Disorder

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500107391
Enrollment
Unknown
Registered
2025-08-11
Start date
2025-08-21
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Generalized anxiety disorder

Interventions

Healthy Control Group:none
tDCS Active Stimulation Group:Transcranial Direct Current Stimulation
tDCS Sham Group:Transcranial Direct Current Stimulation (tDCS) – Sham Stimulation Mode

Sponsors

Affiliated Kangning Hospital of Ningbo University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Healthy Control Group: (1). Normal findings on psychiatric evaluation; (2). Hamilton Anxiety Rating Scale (HAMA) score = 15; (4).Right-handedness; (5). Provision of written informed consent.

Exclusion criteria

Exclusion criteria: 1.Healthy Control Group: (1). Presence of serious medical (somatic) illness; (2). Intellectual disability or mental retardation (IQ < 90); (3). Pregnancy; (4). Personal or first-degree family history of psychiatric disorders; (5). History of psychoactive substance abuse. 2.GAD Patient Group: (1). Comorbid serious medical conditions, infectious diseases, or immunological disorders; (2). Comorbid severe neurological disease, intellectual disability, or organic brain pathology; (3). Pregnancy or current breastfeeding; (4). Receipt of electroconvulsive therapy within the past three months; (5). History of epileptic seizures; (6). Presence of any metal implants.

Design outcomes

Primary

MeasureTime frame
Anxiety Symptom Severity;Cognitive Function Level;Functional Near-infrared Spectroscopy,fNIRS;

Secondary

MeasureTime frame
Depressive Symptom Severity;

Countries

China

Contacts

Public ContactWang Yubo

Affiliated Kangning Hospital of Ningbo University

18510843323@163.com+86 574 26302625

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026