Endoscopic Submucosal Dissection
Conditions
Interventions
A group:During the induction stage, 0.05mg/kg oxycodone was administered by infusion.
B group:During the induction stage, 0.075mg/kg oxycodone was administered by infusion.
C group:During the induction stage, 0.10mg/kg oxycodone was administered by infusion.
D group:During the induction phase, the same dose of 0.9% sodium chloride solution was infused.
Sponsors
Chengdu Second People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.The patient's age is between 60 and 80 years old; 2. 18 < BMI < 30 kg/m^2; 3. Classified by the American Society of Anestesiologists (ASA) as grades I to III; 4. Be able to understand the research process and communicate effectively with researchers; 5. Fully understand and voluntarily participate in this research, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. The preoperative blood pressure of the patient was >160/100 mmHg or 5 pieces/day), or smoking during different aims to test; 12. random 3 months before drinking more than 14 units of alcohol a week (1 = 45 mL 360 mL beer or alcohol amount for 40% of the liquor or 150 mL wine), or in front of the random within 48 h of intake of alcoholic products, or different period teetotalers to test; Within 3 months before 13. random excessive drinking tea, coffee or caffeinated beverages (at least 8 glasses a day, 1 cup = 250 ml); Or consume any food or beverage containing caffeine or xanthine or that may produce caffeine or xanthine after metabolism (such as coffee, tea, chocolate, cola beverages) within 48 hours before randomization; 14. system with neuromuscular disease, mental illness such as don't cooperate with can't communicator; 15. nearly two weeks hypnotic sedative, antipsychotic medications affect sleep and (or) cognitive functions such as drugs, such as class azole pyrazole, clonazepam, melatonin receptor agonists, polymorphism in the hypocretin receptor antagonists and other drugs); 16. cannot restore to cooperate to complete the quality (QoR - 15) rating scale and postoperative fatigue scale (ICFS - 10) scale to fill out.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Score of the Quality of Life (QoR-15) scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| mean arterial pressure;blood pressure;oxyhemoglobin saturation;respiratory rate;heart rate;awakening time;degree of satisfaction;Time of leaving the room;Induction dose of propofol;The number of additional propofol additions;Total usage of propofol;Dosage of oxycodone;hypotension;hyoxemia;Low heart rate;nausea and vomiting; | — |
Countries
China
Contacts
Public ContactLiu Shaoxing
Chengdu Second People's Hospital
Outcome results
None listed