Postoperative Nausea and Vomiting
Conditions
Interventions
Conventional opioid/oligoopiatic anesthesia observation group:None
Sponsors
The Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. American Society of Anesthesiologists (ASA) classification of grade I-II; 2. Female patients aged 18 years or above; 3. Patients scheduled for elective thyroidectomy; 4. Patients planning to receive a triple antiemetic drug regimen (diphenhydramine, palonosetron, dexamethasone) during the operation; 5. Anesthesia methods of general anesthesia or general anesthesia combined with nerve block; 6. Patients and their authorized representatives have agreed to participate in this study and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. Those allergic to anesthetic drugs (such as various general anesthetics and local anesthetics); 2. Patients with coagulation disorders; 3. Those with infection at the puncture site, anatomical deformity or tumor invasion; 4. Those who have had persistent nausea and vomiting symptoms within 3 months before the surgery or regularly use antiemetic drugs; 5. Those with contraindications to non-steroidal anti-inflammatory drugs (such as active gastrointestinal ulcers, severe renal dysfunction, aspirin asthma, etc.); 6. Those with severe neurological diseases or cognitive dysfunction that affect communication and pain/PONV assessment before the surgery; 7. Those who refuse to participate in this study; 8. Those who have used drugs that may affect PONV assessment within 24 hours before the surgery (such as opioids, antiemetics, high-dose hormones, etc.); 9. Those with a long-term history of chronic pain and long-term use of opioids; 10. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative nausea and vomiting;Salvage antiemetics use;Postoperative nausea and vomiting severity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse events (respiratory depression, hyperalgesia, etc.);Restore quality Q15;Patient satisfaction score;Length of hospital stay after surgery;Postoperative opioid dosage;Intraoperative opioid dosage;Time to first require analgesic medication;Postoperative pain score (at rest and when coughing and swallowing); | — |
Countries
China
Contacts
Public ContactLiu Haitao
The Second Hospital of Hebei Medical University
Outcome results
None listed