Major Depressive Disorder, Schizophrenia
Conditions
Interventions
Experimental Group (1.1):Transcranial Ultrasound Stimulation Regulation for 30 patients with depression: In accordance with the experimental protocol, non-invasive and safe transcranial ultrasound sti
Sham Stimulation Group (1.1):The same transcranial ultrasound stimulation device and experimental protocol used in the experimental group were applied to 30 patients with depression, but with the ultr
Experimental Group (1.2):Transcranial Ultrasound Stimulation Regulation for 30 patients with schizophrenia: In accordance with the experimental protocol, non-invasive and safe transcranial ultrasound
Sham Stimulation Group (1.2):The same transcranial ultrasound stimulation device and experimental protocol used in the experimental group were applied to 30 patients with schizophrenia, but with the u
Experimental Group (2.1):Transcranial ultrasound stimulation modulation for 30 patients with depression: According to the requirements of Experiment 2, non-invasive and safe transcranial ultrasound st
Sponsors
Shandong Daizhuang Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1.Meet the DSM-5 diagnostic criteria for depression/schizophrenia as confirmed by the Structured Clinical Interview for DSM-5 (SCID-V); 2.Age >= 16 years; 3.Voluntarily participate in the study, with informed consent obtained from both the participant and their family; 4.Able to understand written language and complete questionnaires; 5.Han Chinese ethnicity, right-handed.
Exclusion criteria
Exclusion criteria: 1. History of substance dependence; other psychiatric disorders or histories meeting SCID Axis I diagnostic criteria; history of traumatic brain injury, epilepsy, or other organic brain diseases; 2. Laboratory tests indicating impaired liver or kidney function, or other severe somatic illnesses and metabolic disorders; 3. Contraindications for TUS or MRI scanning: such as presence of cardiac pacemakers, metallic implants in the body, dental braces, or claustrophobia; 4. Intracranial implants (e.g., aneurysm clips, shunts, stimulators, cochlear implants, or electrodes) or any other metallic objects within or near the head that cannot be safely removed; 5. Any neurological disorders or severe somatic illnesses; 6. Use of certain medications that may interfere with TUS treatment efficacy, such as barbiturates, benzodiazepines, and certain anticonvulsants; 7. History of electroconvulsive therapy (ECT).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fMRI Resting-state Functional Connectivity;Cognitive Task Accuracy;Cognitive Task Reaction Time;Interviews or scale scores related to symptoms; | — |
Countries
China
Contacts
Public ContactKun Li
Shandong Daizhuang Hospital
Outcome results
None listed