Depressive disorder
Conditions
Interventions
Venlafaxine hydrochloride group (VH group):N/A
Desvenlafaxine succinate group (DVS group):N/A
Toludesvenlafaxine hydrochloride group (TVH group):N/A
Sponsors
Zhongda Hospital, Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for depressive disorders in the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) of the United States; 2. The subjects took the medicine as prescribed by the doctor during their hospitalization. 3. During the treatment period, regularly receive treatment drug monitoring and biochemical tests; 4. Age: 18 to 80 years old, gender not limited; 5. With the patient's consent and the signing of the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Accompanied by severe or unstable physical diseases, neurological diseases and other mental disorders; 2. Use the same type of antidepressant within two weeks before treatment, or use two or more of the same type of antidepressant simultaneously in the medication regimen; 3. Women of childbearing age who are breastfeeding, pregnant or have not taken reasonable contraceptive measures; 4. Those who have not responded to SSRI and SNRI drugs in the past, and those who have been allergic to related drugs in the past.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction rate of Hamilton Depression Scale-17 score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale;Plasma drug concentration; | — |
Countries
China
Contacts
Public ContactLingjun Zhong
Zhongda Hospital, Southeast Universtiy
Outcome results
None listed