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Study on Serum Exosome-Derived miRNA as Early Diagnostic Biological Marker for Primary Cervical Dystonia Patients

Study on Serum Exosome-Derived miRNA as Early Diagnostic Biological Marker for Primary Cervical Dystonia Patients

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500107299
Enrollment
Unknown
Registered
2025-08-07
Start date
2024-09-20
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary Cervical Dystonia

Interventions

Gold Standard:Currently, there's no widely accepted diagnostic standard for CD. It mainly depends on the clinical judgment of experienced movement disorder specialists.
Index test:Observation Indexes: 1. Accuracy Assesses if the biomarker can accurately identify cervical dystonia (CD) patients and non - patients by comparing biomarker test results with clinical diagn

Sponsors

The First Affiliated Hospital of Air Force Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria for the Case Group: 1. Aged 18 - 80, any gender. 2. Clinically diagnosed with primary cervical dystonia (CD). 3. Agrees to participate and signs the consent form. Inclusion Criteria for the Control Group: 1. Aged 18 - 80, matched in gender and age with the case group. 2. No personal or family history of neurological or psychiatric diseases or adverse drug reactions. 3. Agrees to participate and signs the consent form.

Exclusion criteria

Exclusion criteria: Exclusion Criteria for the Case Group: Severe cardiovascular disease, especially pacemaker or stent. Other neurological diseases, diabetes, renal infection, tumors, or cognitive impairment. Severe cerebrovascular disease, especially aneurysm clips or stent. Patients with mental disorders. Pregnant, breastfeeding, or family planning individuals. Increased intracranial pressure, intracranial infection, large - area cerebral infarction, cerebral hemorrhage, intracranial tumors, or epilepsy. Severe anemia or coagulation disorders. Subjects deemed unsuitable by researchers. Study Termination Criterion: Patients unable to cooperate with researchers.

Design outcomes

Primary

MeasureTime frame
Accuracy;Sensitivity;Stability;Correlation Analysis; Receiver Operating Characteristic Curve (ROC Curve); Positive Predictive Value (PPV);Negative Predictive Value (NPV);Specificity;

Countries

China

Contacts

Public ContactMing Shi

The First Affiliated Hospital of Air Force Medical University

biomidas@163.com+86 158 9179 3458

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026