None
Conditions
Interventions
Intervention group 5:sham otDCS +sham rTMS
Intervention group 1:otDCS + rTMS, peak synchronization
Intervention group 2:otDCS + rTMS, trough synchronization
Intervention group 3:otDCS + sham rTMS
Intervention group 4:sham otDCS + rTMS
Sponsors
Xuanwu Hospital of Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Male or female aged 18 years (inclusive) to 65 years old (inclusive); 2. No neurological or psychiatric diseases, no history of cardiovascular disease, diabetes and other chronic diseases; 3. No positive findings in the nervous system examination; 4. According to the Edinburgh partial chirality test, they are all right-handed; 5. Subjects voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those with depressive disorders and anxiety disorders, with a total score of >=8 points on the Hamilton Depression Rating Scale (HAMD-17) and a total score of >=8 points on the Hamilton Anxiety Scale (HAMA-14), and mental illnesses such as schizophrenia; 2. Those with serious or unstable organic diseases such as seizures, central nervous system tumors, history of acute head injury or intracranial infection, hydrocephalus, etc.; 3. Those with a history of brain surgery in the past; 4. Pregnant or lactating women, those who plan to become pregnant in the near future; 5. Those who have metal implants such as pacemakers in the body; 6. Those whose skin integrity is impaired at the stimulation site; 7. Those who participated in other neuromodulation interventions within 6 months before enrollment; 8. Long-term alcoholics; 9. Other conditions that the investigator believes are not suitable for participating in this study.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Rate of change of the amplitude MEP relative to baseline;Rate of change of the amplitude MEP relative to baseline;Rate of change of the amplitude MEP relative to baseline;Rate of change of the amplitude MEP relative to baseline;Rate of change of the amplitude MEP relative to baseline;Rate of change of the amplitude MEP relative to baseline; | — |
Primary
| Measure | Time frame |
|---|---|
| Rate of change of the amplitude MEP relative to baseline; | — |
Countries
China
Contacts
Public ContactYuping Wang
Xuanwu Hospital of Capital Medical University
Outcome results
None listed