Postoperative sore throat
Conditions
Interventions
C group with nebulized normal saline:Twenty minutes before anesthesia induction, pour 5 mL of normal saline into the nebulizer and instruct the patient to inhale the nebulized solution, with an estima
C group with nebulized esketamine group:Twenty minutes prior to anesthesia induction, mix 25 mg of esketamine (50 mg/mL, Hengrui Pharmaceuticals, Jiangsu, China) with 4 mL of normal saline to a total
K2 group intravenous administration of esketamine group :Prior to endotracheal intubation, the patient received 25 mg of esketamine via intravenous injection.
Sponsors
The Second Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.>=18 years old; 2.American Society of Anesthesiologists (ASA) physical status I-III; 3.Scheduled for elective surgery under general anesthesia with double-lumen endobronchial intubation; 4.Patients who provided written informed consent.
Exclusion criteria
Exclusion criteria: 1.Known allergy to esketamine; 2.Known or anticipated difficult airway, defined as Mallampati class IV or Cormack-Lehane grade III-IV on laryngoscopy; 3.Pre-existing sore throat, hoarseness, or recent/recurrent respiratory tract infection; 4.Anticipated risk of aspiration; 5.Requirement of oropharyngeal or nasopharyngeal airway during mask ventilation; 6.Poorly controlled or untreated hypertension. 7. Conditions associated with elevated intracranial pressure (ICP), increased intraocular pressure (IOP), or ischemic heart disease; 8. Patients assessed to be at high risk of delirium or otherwise contraindicated for esketamine administration based on comprehensive evaluation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence and severity (Grade 0-3) of postoperative sore throat and hoarseness ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence and severity of dry mouth and cough;Mean arterial pressure and heart rate;Resting and cough-induced wound pain Numeric Rating Scale (NRS) scores ;Postoperative adverse reactions including hallucinations, nausea/vomiting, and agitation; | — |
Countries
China
Contacts
Public ContactHaitao Yang
The Second Hospital of Dalian Medical University
Outcome results
None listed