Patients with central vertigo who have cerebral capillary reactive damage (such as small vessel disease, chronic cerebral ischemia) present with non-rotatory vertigo (floating sensation, imbalance) lasting for several hours, unrelated to body position, and often accompanied by vertical/gaze nystagmus (negative head impulse test). Microcirculatory disorders may cause gait instability (sticky gait),
Conditions
Interventions
Healthy control group:NA
Central vertigo group:NA
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Central Vertigo Group: Age 18–75 years, no gender restrictions; Meets the diagnostic criteria for central vertigo established by the International Barany Society (2020 edition) and has been diagnosed with central vertigo at our hospital; Vertigo symptoms have persisted for >=1 month, and acute cerebral infarction, hemorrhage, or other structural lesions have been ruled out via cranial MRI or CT; Able to cooperate with MRI scanning and CO2 stimulation testing; Has signed an informed consent form and voluntarily participates in the study. 2. Healthy control group: aged 18–75 years, no gender restrictions; no history of vertigo or neurological disorders; no abnormalities detected on cranial MRI; able to cooperate in completing MRI scans and CO2 stimulation experiments; signed informed consent form and voluntarily participated in the study.
Exclusion criteria
Exclusion criteria: 1. Contraindications for MRI (e.g., metallic implants in the body, claustrophobia); 2. Severe cardiovascular or pulmonary conditions (e.g., chronic obstructive pulmonary disease (COPD), heart failure) or inability to tolerate CO2 stimulation; 3. Pregnant or breastfeeding women; 4. Recent (within 1 month) use of vasoactive medications (e.g., calcium channel blockers, nitrates); 5. inability to cooperate with MRI scanning or respiratory control tasks (e.g., severe cognitive impairment); 6. family history of neurological diseases (e.g., Alzheimer's disease, Parkinson's disease); 7. recent (within 6 months) history of major surgery or trauma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral vascular reactivity; | — |
Countries
China
Contacts
Public ContactYu Zhao
West China Hospital, Sichuan University
Outcome results
None listed