depression with fatigue
Conditions
Interventions
health control:none
depression with fatigue:none
Sponsors
Peking University Sixth Hospital ( Institute of Mental Health )
Eligibility
Sex/Gender
All
Age
12 Years to 19 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the control group: 1. aged 12-19 years; 2. literacy skills to complete the questionnaire and psychological assessment; 3. patients and guardians volunteered to be tested and signed an informed consent for the study. Inclusion criteria for the case group: 1. aged 12-19 years old and no limited to gender; 2. meeting the diagnostic criteria for depression in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), with no psychotic symptoms and no serious suicidal tendencies; 3. receiving medication, with no change in medication regimen within 2 weeks; 4. 17 items of the Hamilton Depression Inventory =3 total score on the fatigue scale, with a No change in CGI efficacy score within 2 weeks; 5. No regular exercise in the past and no modified electroconvulsive therapy within 6 months; 6. Patients and guardians voluntarily accepted the test and signed the informed consent for the study.
Exclusion criteria
Exclusion criteria: The control group exclusion criteria: 1. any mental disorder that meets the DSM-5 diagnosis or a first-degree relative with a previous mental disorder or inherited neurological disease; 2. patients with a history of severe cranio-cerebral trauma that triggered a loss of consciousness either currently or in the past, and the presence of cognitive impairment and mental retardation. 3. At present, he suffers from serious unstable somatic diseases, such as diabetes, thyroid disease, hypertension, heart disease, narrow angle glaucoma, etc. 4. There are contraindications for magnetic resonance imaging examination. The case group exclusion criteria: 1. other mental disorders that met the DSM-5 diagnostic criteria, including organic mental disorders, psychoactive substance-induced psychiatric disorders, schizophrenia, bipolar disorder, and autism spectrum disorders; 2. current or previous comorbid neurological disorders or other serious somatic disorders, serious cardiovascular and cerebrovascular disorders, and serious respiratory disorders that preclude the acceptance of exercise; 3. Current or previous history of substance abuse or dependence, family history of mental illness; 4. Current or previous history of severe craniocerebral trauma that triggered loss of consciousness, patients with cognitive impairment, intellectual disability; 5. Contraindications to magnetic resonance examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fatigue; | — |
Secondary
| Measure | Time frame |
|---|---|
| social function;sleep quality;clinical efficiency;depressive symptoms;cognitive function;subjective cognitive function;Non-suicidal self-injury;neuroimageing;anhedonia;depressive symptoms; | — |
Countries
China
Contacts
Public ContactChuan Shi
Peking University Sixth Hospital ( Institute of Mental Health )
Outcome results
None listed