Bacterial vaginosis
Conditions
Interventions
Intervention group:Lactobacillus intervention
Control group:Placebo
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1.Premenopausal women aged 18 to 45 years; 2. No recent use of hormones, antibiotics, or vaginal drugs (no vaginal irrigation within 5 days and no vaginal sex within 48 hours); 3. Meets at least three of Amsel's four criteria (i.e., thin, white or yellow, uniform discharge; 20% of the clue cells were > in microscopic examination; vaginal fluid pH >4.5; fishy odor is released when 10% potassium hydroxide is added to vaginal samples); Nugent Score (4-10) 4. Those who sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnancy status; 2. Patients suffering from AIDS, syphilis, hepatitis and other infectious diseases; 3. Negative swab positive molecular test for gonorrhea, chlamydia and trichomoniasis infection; 4. Urine sample test suggests urinary tract infection; 5. Patients who have been taking hormonal drugs and immunosuppressant drugs for a long time; 6. Patients who need to take antibiotics during the chronic inflammation study; 7. Patients with severe vulvar and vaginal itching symptoms; 8. Not signed informed consent; 9. Inability to follow up regularly; 10. Inability to use Lactobacillus vaginalis preparations continuously for 1 week after the end of metronidazole treatment; 11. Other conditions that the investigator deems unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amsel criteria;Nugent score; | — |
Countries
China
Contacts
Public ContactLan Zhu
Peking Union Medical College Hospital
Outcome results
None listed