Acute respiratory distress syndrome
Conditions
Interventions
Experimental group:Nitric oxide and conscious prone position treatment alone or in combination
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old, gender is not limited; 2. Patients with spontaneous breathing and clear consciousness can cooperate with breath hold for 5 seconds; 3. Non-invasive ventilation with PEEP or CPAP>=5mmHg or high-flow oxygen therapy with a flow rate >=30L/min, which meets the new global diagnostic criteria for non-intubated ARDS: PaO2/FiO2<=300mmHg or SpO2/FiO2<=315 (SpO2<=97%); 4. Patients or their families agree to participate in this trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Respiratory fatigue symptoms: RR>40/min, PaCO2>50mmHg/pH<7.30, and obvious use of auxiliary respiratory muscles; 2. Patients in urgent need of intubation (PaO2/FiO2<50 mmHg, unable to protect the airway or change mental status); 3. Hemodynamic instability, i.e., an increase of more than 30% of vasoactive drugs within 6 hours, or a dose of norepinephrine more than 0.5mcg/kg/min; 4. Contraindications to EIT monitoring, such as implantation of a pacemaker; 5. Patients who cannot perform awake prone position after severe facial trauma, severe chest and abdominal trauma, unfixed fractures, etc.; 6. Patients with chronic obstructive pulmonary disease, pulmonary embolism or pulmonary fibrosis; 7. Patients with intracranial hypertension, severe arrhythmia or gastrointestinal obstruction; 8. Pregnant or lactating; 9. Need to receive extracorporeal membrane oxygenation therapy; 10. Patients who are participating in other studies. The experimental protocol is approved by the ethics committee, and the patient or his client signs the informed consent form; 11. Other conditions in which the clinician believes that the patient is not suitable for inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenation index; | — |
Countries
China
Contacts
Public ContactLiu Kai
Zhongshan Hospital Affiliated to Fudan University
Outcome results
None listed