Gastrointestinal tumors
Conditions
Interventions
Opioid-free group:General anesthesia without opioids
Routine general anesthesia group:General anesthesia including sufentanil and remifentanil was used
Sponsors
Yancheng Third People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age range: Adult patients between the ages of 40 and 80; 2. Gender: Both male and female can be included; 3. Diagnosis establishment: Patients with gastrointestinal malignant tumors diagnosed clinically or pathologically, including gastric cancer, colon cancer, rectal cancer, etc; Surgical type: Patients who plan to undergo open or laparoscopic radical resection of gastrointestinal tumors.; 5. Immune function: there is no serious immune function defect or immunosuppression related disease (such as AIDS or long-term use of immunosuppressants) before operation; Anesthesia requirements: Patients are suitable for receiving either a de opioid anesthesia regimen or a traditional anesthesia regimen (based on anesthesia risk assessment).; 7. Physical condition: The American Society of Anesthesiologists (ASA) score ranges from I to III, indicating that the patient has the basic physical conditions to undergo surgery; 8. Informed consent: Patients voluntarily participate in the study, sign an informed consent form, comply with the trial protocol, and complete follow-up as required.
Exclusion criteria
Exclusion criteria: 1. Allergy to known drugs; 2. Trauma and infection at the block site, abnormal coagulation function; 3. Preoperative bradycardia (heart rate <50 beats/minute), hypotension, atrioventricular block, intraventricular or sinus block, left ventricular ejection fraction <40%; 4. Chronic abuse of analgesic medications; 5. Severe organ (heart, lung, liver, kidney) insufficiency, neurologic disease; 6. Patients with severe autoimmune system disorders; 7. Patients who have undergone immunotherapy before surgery; 8. Patients who are incapable of self-care or have speech and communication disorders; 9. Refusing to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| natural killer cell; CD4+ /CD8+ ; IFN-? ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Extubation time;Duration of stay in post-anesthesiacare unit;Total hospital stay; | — |
Countries
China
Contacts
Public ContactHang Zhao
Yancheng Third People's Hospital
Outcome results
None listed