Patients in the ICU who need fiberoptic bronchoscopy for mechanical ventilation
Conditions
Interventions
Phosphopropofol disodium group:Phosphopropofol disodium
Propofol group:Propofol
Sponsors
Liaocheng People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old and <=75 years old, gender not limited; 2. Patients admitted to the ICU who require invasive mechanical ventilation and fiberoptic bronchoscopy; 3. Obtain the informed consent of the patient or their family.
Exclusion criteria
Exclusion criteria: 1. Pregnancy or breastfeeding; 2. Patients with a history of alcohol or drug abuse; 3. Patients with acute hepatitis and severe liver diseases (Child-Pugh grade C); 4. Bradycardia (second/third degree atrioventricular block); 5. Receiving two or more sedative or analgesic drugs in the ICU within 24 hours; 6. Patients allergic to disodium phosphopropofol and propofol; 7. Any situation that hinders the correct assessment of cognitive function, such as language and sensory disorders or mental disorders (language difficulties or mental organic functional disorders); 8. Unable to obtain informed consent or authorization; 9. Participate in other exploratory clinical trials within 6 months before screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time it takes to achieve the ideal sedation goal;The time it takes to regain consciousness after the examination;Operation time of bronchoscopy;The number of cases that failed to reach the sedation target; | — |
Secondary
| Measure | Time frame |
|---|---|
| hospital stays;Changes in heart rate, blood pressure, blood oxygen saturation and respiratory rate per minute;Incidence of adverse events;In-hospital /ICU mortality rate;icu staying;The occurrence of bronchospasm; | — |
Countries
China
Contacts
Public ContactTian Hui
Liaocheng People's Hospital
Outcome results
None listed