Chronic Helicobacter pylori gastritis
Conditions
Interventions
Group 1 of keverprazan combined with amoxicillin:Keverprazan 20 mg, twice daily (bid) + amoxicillin 1 g, bid, for 14 days
Group 2 of keverprazan combined with amoxicillin:Keverprazan 20 mg, twice daily (bid) + amoxicillin 1 g, 3 times a day (tid), for 14 days.
Sponsors
The First AfiliatedHospital of Fujian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.18 years old <= age <= 65 years old, gender is not limited; 2. Helicobacter pylori (Hp) test is positive (confirmed by 13C-urea breath test, 14C-urea breath test, HE staining or bacterial culture); 3. No history of Hp eradication treatment; 4. Endoscopy report within the past year confirms chronic gastritis; 5. Able to independently complete the diary card of the subject; 6. Fully understand the content of the trial, voluntarily participate in the trial and be able to complete the trial process, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Active peptic ulcer with complications such as bleeding, perforation, obstruction, and cancer; 2. Previous history of esophageal or gastric surgery; 3. Severe systemic disease, major organs such as heart, lung, brain disease, liver and kidney dysfunction, other malignant tumors or other diseases; 4. Known allergy to Keverprazan, amoxicillin and related excipients (such as mannitol, microcrystalline cellulose, cross-linked polyvinylpyrrolidone, hydroxypropyl cellulose, magnesium stearate, etc.); 5. Pregnant or lactating women; 6. Long-term alcohol abuse or any other situation that increases the risk of adverse drug reactions; 7. Participated in other acid-reducing drug studies within the past 3 months, unable to express their thoughts correctly or unable to cooperate with researchers; 8. Researchers believe that other participants are not suitable for the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hp eradication rate after 4 weeks of eradication therapy; | — |
Countries
China
Contacts
Public ContactChengdang Wang
The First AfiliatedHospital of Fujian Medical University
Outcome results
None listed