Gout
Conditions
Interventions
intervention group:Fixed-dose febuxostat (40 mg once daily) plus PIP strategy: colchicine was given as a loading dose of 1 mg within 12 hours of the patient experiencing a gouty aura such as tingling
control group:Fixed-dose febuxostat (40 mg once daily) plus low-dose colchicine (0.5 mg once daily)
Sponsors
The Second Affiliated Hospital Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Male patients older than 18 years of age; 2. Experienced at least one gouty arthritis attack within one year prior to study enrollment; 3. Serum uric acid level greater than 7.0 mg/dL; 4. Not on uric acid-lowering medication for at least one month prior to study entry; 5. Participants should have experienced at least one gouty aura.
Exclusion criteria
Exclusion criteria: 1. Patients who have had gouty arthritis in the two weeks prior to the study date; 2. Are younger than 18 years of age; 3. History of allergy to febuxostat, colchicine, or NSAIDs; 4. Serious comorbidities, including serum creatinine levels of 2.0 mg/dL or greater; 5. Patient is considered by the investigator to be unsuitable for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of gouty attacks; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cumulative dose of colchicine;Percentage of patients achieving blood uric acid <=6.0 mg/dL;Adverse events and adverse reactions; | — |
Countries
China
Contacts
Public ContactLei Liu
The Second Affiliated Hospital Zhejiang University School of Medicine
Outcome results
None listed