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The Impact of Opioid-Sparing Anesthesia and Analgesia on Postoperative Pain and Sleep-Related Respiratory Events in Patients at risk for Obstructive Sleep Apnea Undergoing Open Upper Abdominal Surgery: A Single-Center Randomized Controlled Non-Inferiority Clinical Trial

The Impact of Opioid-Sparing Anesthesia and Analgesia on Postoperative Pain and Sleep-Related Respiratory Events in Patients at risk for Obstructive Sleep Apnea Undergoing Open Upper Abdominal Surgery: A Single-Center Randomized Controlled Non-Inferiority Clinical Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500107146
Enrollment
Unknown
Registered
2025-08-05
Start date
2025-08-11
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive Sleep Apnea

Interventions

Opioid-Sparing Anesthesia and Analgesia Group:Opioid-Sparing Anesthesia and Analgesia
Routine Anesthesia Group:routine anesthesia

Sponsors

Zhongshan Hospital, Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. age > 18 years and < 80 years 2. Patients with confirmed OSA and high-risk or intermediate-risk OSA were screened by STOP-BANG scale 3. Under general anesthesia combined with epidural anesthesia, open surgery of the upper abdomen was planned 4. American Society of Anesthesiologists (ASA) Class I-II 5. Ethically, patients volunteered and signed an informed consent form

Exclusion criteria

Exclusion criteria: 1. Those with a history of neuropsychiatric disease before operation 2. Long-term use of psychotropic drugs, analgesics, history of alcoholism 3. There were consciousness disorder, language disorder and communication disorder before operation 4. Patients with severe heart, lung, liver and kidney dysfunction 5. People who are allergic to the test drug 6. Patients admitted to ICU after surgery

Design outcomes

Primary

MeasureTime frame
Pain;

Secondary

MeasureTime frame
Quality of recovery score;4% oxygen reduction index;Sleep quality;

Countries

China

Contacts

Public ContactXiaoguang Zhang

Zhongshan Hospital Affiliated to Fudan University

zhang.xiaoguang@zs-hospital.sh.cn+86 136 4199 5733

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026