hypotension
Conditions
Interventions
Propofol Group:According to the routine anesthesia plan of each center (traditional anesthetics such as propofol and etomidate can be used), anesthesia induction and maintenance should be carried out.
Remimazolam Group:Use 0.25 mg/kg of remimazolam for anesthesia induction. There are no specific restrictions on analgesics and muscle relaxants, and the administration time should be completed within
If the patients consciousness disappears, maintenance medication will be administered. The criteria for consciousness disappearance after administration are: Modified Alert Sedation Score (MOAA/S scor
If the MOAA/S score of the patient is = 2 or the eyelash reflex does not disappear 3 minutes after the first administration, remimazolam 0.05mg/kg should be given again as a remedy. If consciousness d
In addition, no other sedatives are used
Retrospective experimental group:None
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients undergoing elective surgery under total intravenous anesthesia; 2.Gender not limited, age between 18 and 65 years old; 3. Body mass index (BMI) 18.5-28kg/m2; 4.ASA classification is I-III level; 5. No previous history of anesthesia drug allergies 6. There are no significant abnormalities in the heart, liver, lungs, or coagulation function; 7.Expected surgical duration not exceeding 4 hours; 8. Patients who are not expected to enter the ICU after surgery; 9. Voluntary signing of informed consent form.
Exclusion criteria
Exclusion criteria: 1.Individuals with allergic reactions to the drugs in this study; 2.Individuals with severe heart and lung dysfunction, liver and kidney dysfunction; 3. Patients with mental system disorders (such as schizophrenia, depression, etc.) and cognitive impairment; 4.Patients who have experienced acute upper respiratory tract infections and persistent asthma attacks in the past two weeks; 5.Patients who are highly likely to experience difficult airways (such as severe snoring, pathological obesity patients); 6.Long term use of sedatives, hypnotics, or psychotropic drugs; Pregnant or lactating women; 7.The researcher determines that the subjects are not suitable to participate in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| MMSE score;Anesthesia awakening time;Time for extubation of tracheal tube;Duration of stay in the recovery room; | — |
Countries
China
Contacts
Public ContactLin Yunan
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed