Cervical Precancerous Lesions
Conditions
Interventions
Index test:PAX1 and JAM3 gene methylation testing
Sponsors
Shanghai Fengxian District Central Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or older and with a history of sexual activity. 2. Underwent cervical cancer screening at our hospital, including cytology (TCT), high-risk HPV (hrHPV) DNA testing, HPV E6/E7 mRNA testing, and PAX1/JAM3 gene methylation testing.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women may have their test results affected by their physiological conditions; 2. Patients with HIV infection may exhibit abnormal immune status, which could affect the natural course of HPV infection and the accuracy of related test results. Similarly, individuals with a history of organ transplantation may experience persistent HPV infection and accelerated progression of cervical lesions due to long-term use of immunosuppressive agents. 3. Patients with autoimmune diseases (such as systemic lupus erythematosus or rheumatoid arthritis) or those receiving immunosuppressive therapy may have impaired immune function, which could interfere with the natural course of HPV infection.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| AUC;accuracy; | — |
Primary
| Measure | Time frame |
|---|---|
| specificity;sensitivity; | — |
Countries
China
Contacts
Public ContactRong Zhang
Shanghai Fengxian District Central Hospital
Outcome results
None listed