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Effect of Different Sequences of Administration of Remimazolam and Alfentanil on Adverse Reactions During the Anesthetic Induction Period in Gynecological Day Surgery Patients

Effect of Different Sequences of Administration of Remimazolam and Alfentanil on Adverse Reactions During the Anesthetic Induction Period in Gynecological Day Surgery Patients

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500107098
Enrollment
Unknown
Registered
2025-08-04
Start date
2025-08-15
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None

Interventions

AR group:Alfentanil 20ug / kg 1min time-limited infusion Remazolam 0.25 mg / kg was infused within 1 min.
RA group:Remazolam 0.25 mg / kg was infused within 1 min. Alfentanil 20ug / kg 1min time-limited infusion

Sponsors

Weifang People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: ( 1 ) Age 18-65 years old ; ( 2 ) Body mass index ( BMI ) 18~ 28kg / m^2 ; ( 3 ) The American Association of Anesthesiologists (ASA) graded ?~?; ( 4 ) Patients undergoing gynecological day surgery under general anesthesia.

Exclusion criteria

Exclusion criteria: ( 1 ) admission blood pressure > 180 / 110 mmHg ; severe bradycardia ( HR < 50 beats / min ) ; ( 2 ) Severe respiratory and circulatory system diseases or liver and kidney dysfunction ; ( 3 ) Allergic to related drugs in this study ; ( 4 ) mental or cognitive dysfunction ; ( 5 ) long-term use of analgesic or sedative drugs ; ( 6 ) Patients with intractable hiccups and difficult airways

Design outcomes

Primary

MeasureTime frame
Incidence of adverse reactions ( hiccups, body movement, injection pain ) during anesthesia induction period;

Secondary

MeasureTime frame
Remazolam loss of consciousness time;Vital signs at different time points ( blood pressure, heart rate, oxygen saturation, anesthesia consciousness index );The patient 's recovery time;General information of patients;

Countries

China

Contacts

Public ContactJi Fanceng

Weifang People's Hospital

jifanceng@163.com+86 135 6369 8838

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026