post-inflammatory hyperpigmentation (PIH)
Conditions
Interventions
A area:Apply sample MT4207517 before laser treatment (pre-treated)
B area :Apply sample MT4207518 after laser treatment (post-treated)
C area :Apply sample MT4207517 before laser treatment and apply sample MT4207518 after laser treatment (pre+post-treated)
D area : only laser treatment, not apply sample (untreated)
Sponsors
Shanghai Skin Disease Hospital(Skin Disease Hospital of Tongji University)
Eligibility
Sex/Gender
Female
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Subject is female between 20 and 65 years of age, in general good health; 2. Subject has signed an Informed Consent Form; 3. Subject is dependable and agree to adherent to study requirements; 4. Test area skin type III to IV (50% subjects 28< ITA < 40; 50% subjects ITA < 28); 5. Subject is suitable for CO2 aesthetic dermatological procedure at Docter’s discretion and can accept the discomfort during the process; 6. Subjects are required to avoid exposing herself to sun and protective measures will be utilized to avoid excessive sun exposures; 7. Subjects agree not to wear any other cosmetic or personal care products, other than the assigned test products including ancillary product-cleanser, moisturizer, during the course of the study.
Exclusion criteria
Exclusion criteria: 1. Subject reports being pregnant or nursing or planning pregnant; 2. Subject has any cutaneous disorders which may affect test results; 3. Subject is currently using, or has routinely used within one month prior to study initiation, any systemic or topical corticosteroids, vasoconstrictors, antibiotics, anti-inflammatory medications or other dermatological medications; 4. Subject has any medical treatments which could influence the outcome of the study in the past 2 months. 5. Subject has known allergies to cosmetics, sunscreens, or personal care products; 6. Subject has participated in any investigational systemic drug study within two months of study initiation; 7. Subject is currently using, or has routinely used within two weeks prior to study initiation, any antihistamines; 8. Subject has participated in a clinical or cosmetic study within one month of study initiation; 9. Subject has a history of acute or chronic dermatologic, medical, and/or physical conditions which would preclude application of the test product and/or could influence the outcome of the study. 10. Subject has immune deficiency, autoimmune diseases, or highly sensitive constitution; 11. Investigator considers any other unsuitable condition to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ITA°; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical degree of PIH;Clinical degree of erythema;Clinical degree of edema and scab;image of skin;Reflectance confocal microscopy;Optical coherence tomography;Fluoresence spectroscopy; | — |
Countries
China
Contacts
Public ContactYimei Tan
Shanghai Skin Disease Hospital(Skin Disease Hospital of Tongji University)
Outcome results
None listed