respiratory failure difficult weaning
Conditions
Interventions
Combined Diaphragm-Abdominal Muscle Electrical Stimulation Therapy Group:Combined Diaphragm and Abdominal Muscle Electrical Stimulation
Conventional Therapy Control Group:Conventional therapy comprised: passive and active limb exercise training, targeted treatment of underlying diseases,
nutritional support therapy, and other standard
Sponsors
The Second Medical Center, Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
80 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 80 years; 2. Nasotracheal intubation with mechanical ventilation = 48 hours; 3. Difficult weaning with respiratory muscle dysfunction.
Exclusion criteria
Exclusion criteria: 1. Absence of respiratory muscle dysfunction; 2. Pre-existing neuromuscular disorders (e.g., myasthenia gravis) or use of neuromuscular blocking agents during the study; 3. Chest or rib fractures; known anatomical abnormalities of the diaphragm or abdominal muscles; 4. Contraindications to diaphragm/abdominal electrical stimulation, including: History of thoracotomy or laparotomy; Pneumothorax or pneumomediastinum; Active pulmonary tuberculosis; Pleural adhesions;Implanted cardiac pacemaker; 5. Hemodynamic instability; 6. Inadequate imaging window for diaphragm/abdominal muscle assessment due to: Unhealed thoracic/abdominal wounds; Elevated intra-abdominal pressure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day ventilator liberation success rate;duration of mechanical ventilation; | — |
Secondary
| Measure | Time frame |
|---|---|
| diaphragmatic excurtion;diaphragmatic thickness;diaphragmatic thickening fraction;abdominal muscle thickness;abdominal muscle thickening fraction;semi-quantitative assessment of cough ability; | — |
Countries
China
Contacts
Public ContactAn Li
The Second Medical Center, Chinese PLA General Hospital
Outcome results
None listed