Acne vulgaris
Conditions
Interventions
Doxycycline group:Patients received oral doxycycline (50-100 mg/day) for 6 weeks (product of Baotong Pharmaceutical Co., Ltd., Jiangsu Province)
the dosage was adjusted based on adverse events. Meanwhile, the left side of the face received combined red and blue light therapy twice weekly, utilizing red light at 625nm ± 10nm and blue light at 4
The isotretinoin group:Patients received oral low-dose isotretinoin (10-20 mg/day, 0.13-0.36 mg/kg/day
Donghai Pharmaceutical, Shanghai, China) for 6 weeks, with administration advised with meals to reduce the risk of gastrointestinal side effects and enhance drug absorption
the dosage was adjusted based on adverse events. Meanwhile, the lef
Sponsors
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushuhu Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years, gender not specified; 2. Meets the diagnosis of moderate-to-severe (acne vulgaris) according to the Global Acne Grading System (GAGS) score; 3. Capable of understanding and voluntarily signing a written informed consent form, able to complete treatment and follow-up as required.
Exclusion criteria
Exclusion criteria: 1.Pregnant or breastfeeding; 2.History of hypertrophic scars or keloids; 3.Received skin resurfacing treatments (including laser or chemical peels) or systemic corticosteroids or isotretinoin within 6 months prior to the first treatment; 4. Systemic diseases, such as immunodeficiency disorders, diabetes, lupus, etc.; 5. Neurological or psychiatric disorders. 6. During the study, patients were informed not to use any other acne treatments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Global Acne Grading System; | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of Lesion Reduction;Efficacy Rate;Evaluation of Subject Satisfaction; | — |
Countries
China
Contacts
Public ContactMin Li
The Fourth Affiliated Hospital of Soochow University (Dushuhu Hospital, Suzhou)
Outcome results
None listed