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Causal effect of frailty index on renal complications in type 2 diabetes mellitus: Mendelian randomization and clinical relevance analysis

Causal effect of frailty index on renal complications in type 2 diabetes mellitus: Mendelian randomization and clinical relevance analysis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500107040
Enrollment
Unknown
Registered
2025-08-01
Start date
2025-08-01
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes mellitus (T2DM)

Interventions

Type 2 Diabetes Mellitus With Renal Complications:None
Type 2 Diabetes Mellitus Without Renal Complications:None

Sponsors

The Affiliated Shunde Hospital of Jinan UniversityFoshanGuangdong Province
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age >=18 years old; 2. Definitive diagnosis of end-stage renal disease (ESRD); 3. Receiving regular maintenance hemodialysis treatment with dialysis time >=3 months; 4. Receive dialysis 3 times a week, and the treatment compliance is good;

Exclusion criteria

Exclusion criteria: 1.Combined with other systemic malignant tumors; 2.There is severe liver failure or cardiac insufficiency (NYHA grade III or above); 3.Combined with severe immune system diseases, acute poisoning or active infections; 4.Patients with cognitive impairment or mental illness who are unable to cooperate in completing the interview assessment;

Design outcomes

Primary

MeasureTime frame
Frailty Index;Handgrip Strength;Body Mass Index;

Secondary

MeasureTime frame
Comorbidities;Fall History;Blood Pressure;

Countries

China

Contacts

Public ContactHuanhua Wu

The Affiliated Shunde Hospital of Jinan University

1271362080@qq.com+86 757 2361 0946

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026