None
Conditions
Interventions
Cyclopofol group :The initial dose of cyclopofol was 0.5mg/kg, and the administration was completed by slow intravenous injection within 30s. The OAA/S score was performed every 30 seconds after the
If a negative indicator occurs, the next child will receive an escalating dose of cranpopol. The study starts with the first two patients with negative reactions and ends when there are 7 positive and
Combination of esketamine and cyclopofol group:Intravenous ketamine 0.5mg/kg plus cyclopofol 0.5mg/kg was used as the starting dose, and the administration was completed by slow intravenous injection
Sponsors
Third Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
1 Years to 4 Years
Inclusion criteria
Inclusion criteria: 1. Children undergoing elective general anesthesia surgery 2. ASA classification I or II; 3. Age range of 1-4 years old; 4. Gender is not limited 5. Body mass index 13-20kg/m2;
Exclusion criteria
Exclusion criteria: 1.Patients with anemia, malnutrition, or significant hepatic/renal dysfunction; 2.Severe cardiovascular diseases; 3.Intellectual disability; 4.Neuropsychiatric disorders; 5.History of hypersensitivity to anesthetic agents; 6.Chronic use of sedative-hypnotic medications within 30 days prior to enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 50% effective dose; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;Heart rate;Pulse oximetry;Adverse drug reactions during the trial period(hypertension);Adverse drug reactions during the trial period(hypotension);Adverse drug reactions during the trial period(hiccups);Adverse drug reactions during the trial period(cough);Adverse drug reactions during the trial period(nausea and vomiting);Adverse drug reactions during the trial period(logorrhea);Adverse drug reactions during the trial period(body movement);Adverse drug reactions during the trial period(injection Pain); | — |
Countries
China
Contacts
Public ContactZhang Yu
Third Affiliated Hospital of Zhengzhou University
Outcome results
None listed