The thrombus in the left ventricle
Conditions
Interventions
The test group-the group with normal dosage of rivaroxaban:None
The test group-the group with small dosage of rivaroxaban:None
The control group- the warfarin group:None
The control group- no anticoagulation group:None
Sponsors
Tianjin chest hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Patients with LVT caused by coronary heart disease (The formation of LVT occurring in a low-flow and low-shear environment). Patients with more than two TTE follow-ups. Patients discharged alive.
Exclusion criteria
Exclusion criteria: Patients with LVT caused by non-coronary heart disease. Patients with LVT involving mechanical circulatory assist devices (The formation of LVT is predominantly in contact pathway but not mediated in a low-flow and low-shear environment ). Patients died during the index hospitalization or died before oral anticoagulants taking effect. Patients who were lost to follow up, refused to follow up or followed up with less than two times of TTE. Patients with LVT disappeared during only subcutaneous LMWH injection. Patients with other oral anticoagulants such as dabigatran, apixaban. Patients with severe renal failure [creatinine clearance (CrCl) < 15 mL/min] and severe liver diseases (transaminase exceeded the reference value by more than 3 times).However, severe liver and kidney function damage caused by transient reasons were not excluded. Patients with technically limited 2D-TTE, which prevented assessment of the presence of thrombus. Pregnancy and confirmed hematologic diseases (except mild or moderate anemia).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The resolution rate of left ventricular thrombus; | — |
Secondary
| Measure | Time frame |
|---|---|
| The rate of composite endpoints;The rate of embolism;The rate of bleeding;The rate of death ;The rate of major adverse cardiovascular events (MACE); | — |
Countries
China
Contacts
Public ContactWei Zhang
Tianjin chest hospital
Outcome results
None listed