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Efficacy and Neural Mechanisms of Temporally Interfering Stimulation in Post-Stroke Upper Limb Hemiplegia Rehabilitation

Efficacy and Neural Mechanisms of Temporally Interfering Stimulation in Post-Stroke Upper Limb Hemiplegia Rehabilitation

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500107031
Enrollment
Unknown
Registered
2025-08-01
Start date
2025-08-01
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

Control group:tTIS pseudostimulation + conventional rehabilitation
Stimulation group:tTIS + conventional rehabilitation

Sponsors

Department of Rehabilitation Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. The first unilateral stroke is confirmed by computed tomography (CT) or MRI and the diagnosis is in line with the consensus of "Diagnostic Guidelines for Various Major Cerebrovascular Diseases in China 2019" formulated by the Cerebrovascular Disease Group of the Neurology Branch of the Chinese Medical Association. 2. More than 2 weeks and less than 3 months of onset; 3. Those with an FM-UE score of =1) were included in the study 4. 18 years old< = age< = 80 years old; 5. No significant cognitive impairment, stable vital signs, no neurological disorders; 6. Voluntarily participate and sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Those who have had severe heart, lung, liver, kidney and other important organ failure in the past, and those who have poor control of uncontrollable hypertension, arrhythmia, severe coronary heart disease, and diabetes comorbidities; 2. Bilateral encephalopathy, combined with other neurological diseases (Parkinson's, epilepsy, etc.); 3. Severe cognitive impairment, cranial defect, mental disorder, or pregnancy; 4. There are contraindications to MRI, such as intracranial or external metal, pacemakers, drug pumps, etc. in internal devices; 5. Those who cannot complete the basic course of treatment and have poor compliance; 6. Received similar interventions in the past 6 months or are currently participating in other clinical studies.

Design outcomes

Primary

MeasureTime frame
ADL assessment:MB;Assessment of upper limb function:Fugl-Meyer;Muscle tone rating :M Ashworth; Functional near-infrared spectroscopy (fNIRS) acquisition ;

Countries

China

Contacts

Public ContactGuangxu Xu

Suzhou Municipal Hospital

xuguangxu1@126.com+86 139 5173 1331

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026