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Gut Microbiota Profiles and Pre- to Postoperative Dynamics in Patients with Spinal Deformities Compared to Healthy Controls: A Preliminary Longitudinal Comparative Study

Gut Microbiota Profiles and Pre- to Postoperative Dynamics in Patients with Spinal Deformities Compared to Healthy Controls: A Preliminary Longitudinal Comparative Study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500107028
Enrollment
Unknown
Registered
2025-08-01
Start date
2025-08-01
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Congenital scoliosis

Interventions

Congenital scoliosis group:None
Healthy control group:None
3M post-op CS patients group:None
6M post-op CS patients group:None
12M post-op CS patients group:None

Sponsors

Peking Union Medical College Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patient Inclusion Criteria: 1. Age: 0-18 years old is recommended; 2. Visiting or receiving treatment in the Department of Orthopedics of Peking Union Medical College Hospital due to spinal deformity diseases; 3. No digestive system-related diseases in the past three years; 4. No history of smoking, alcoholism or metabolic disease; 5. No use of probiotics or antibiotics in the past 8 weeks; 6. Voluntarily participate and sign the informed consent form; If you are under 14 years old, informed consent from your guardian is required and the informed consent form is signed. Selection criteria for healthy volunteers 1. Age: 0-18 years old is recommended; 2. Being treated or receiving treatment for other non-spinal deformities and other genetic diseases in the Department of Orthopedics of Peking Union Medical College Hospital; 3. Relatives of the same age of the patient without hereditary diseases such as spinal deformity; 4. No digestive system-related diseases in the past three years; 5. No history of smoking, alcoholism or metabolic diseases; 6. No use of probiotics or antibiotics in the past 8 weeks; 7. Voluntarily participate and sign the informed consent form; If you are under 14 years old, informed consent from your guardian is required and the informed consent form is signed.

Exclusion criteria

Exclusion criteria: Patient Exclusion Criteria: 1. Patients who do not meet the inclusion criteria will be excluded; Healthy volunteer exclusion criteria: 1. Patients with other genetic disorders are excluded from the study.

Design outcomes

Primary

MeasureTime frame
Amplicon Sequence Variant, ASVs;

Countries

China

Contacts

Public ContactJianguo Zhang

Peking Union Medical College Hospital

pengzhm5@mail2.sysu.edu.cn+86 198 6794 9466

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026