Skip to content

Comparison of clinical efficacy of CGF combined with collagen pulp regeneration and root canal treatment: a randomised controlled trial.

Comparison of clinical efficacy of CGF combined with collagen pulp regeneration and root canal treatment: a randomised controlled trial.

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500107010
Enrollment
Unknown
Registered
2025-08-01
Start date
2025-08-01
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irreversible pulpitis

Interventions

Experimental group:Pulp regeneration is completed using root canal preparation, root canal irrigation, and injectable CGF root canal filling.
Control group:Root canal treatment is completed with root canal preparation, root canal irrigation, and iRoot SP root canal filling.

Sponsors

The Third Affiliated Hospital of the Air Force Military Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: (1) Patients aged 18 to 45 years old, regardless of gender; (2) Affected teeth diagnosed with irreversible pulpitis; (3) X-ray showed that there was no filling in the root canal, the apical foramen was developed and closed, the periapical cavity was normal or the periapical membrane cavity was widened, and there was no apical low-density transmission. (4) Those who voluntarily participate in this clinical trial and sign the informed consent form.

Exclusion criteria

Exclusion criteria: (1) Patients with severe systemic diseases;(2) Pregnant and lactating women;(3) Teeth with hidden cracks, crown folds or root fractures;(4) Internal or external absorption of tooth roots;(5) There are no opposing teeth;(6) No contact with adjacent teeth;(7) The curvature of the root canal is greater than 45 degrees;(8) Chronic periodontal disease, periodontal pus, abnormal loosening of tooth roots;(9) The root canal cannot be effectively dredged to the apex;(10) Root canal perforation or separation of root canal instruments;(11) There is a large area of defect in the affected tooth body, which cannot be repaired in the later stage;(12) Severe calcification of the root canal or atresia of the medullary cavity;(13) Patients who are allergic to anesthetics;(14) Patients who are allergic to sodium hypochlorite;(15) Patients who use drugs that affect bone resorption.

Design outcomes

Primary

MeasureTime frame
Clinical indicators;Imaging indicators;

Countries

China

Contacts

Public ContactKuang Rong

The Third Affiliated Hospital of the Air Force Military Medical University

1539430163@qq.com+86 29 8477 6078

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026