None
Conditions
Interventions
Control group:The contralateral eye area (non-product usage side) receives one session of Fotona 4D treatment and uses no products
Experimental group:Subjects apply the sample to one randomly selected eye area once in the morning and once in the evening, and use it continuously for 28 days
Sponsors
Dematology Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. 18~60 years old, healthy female or male; 2. There is a certain degree of under-eye lines (grade 3 and above) and crow's feet (grade 3 and above) on the face (wrinkle grading refers to the skin aging atlas (Book 2 Asian)); 3. Able to receive Fotona 4D treatment in the eye; 4. Have daily skin care habits and use eye cream; 5. Facial skin sagging; 6. Good compliance with the project and good communication skills; 7. Willing to follow up and undergo relevant non-invasive testing; 8. Able to understand the trial process, voluntarily participate in the trial and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those who have applied any topical drugs to the test site in the past two months; 2. Those who have used antihistamines in the past week or immunosuppressants in the past month; 3. Those with inflammatory skin diseases that have not been clinically cured; 4. Patients with insulin-dependent diabetes; 5. Patients with asthma or other chronic respiratory diseases who are being treated; 6. Those who have received anti-cancer chemotherapy in the past six months; 7. Patients with immunodeficiency or autoimmune diseases; 8. Women who are planning to become pregnant, pregnant or breastfeeding; 9. Those who have obvious scars, pigments, atrophy, bright red moles, sun spots, wounds, abrasions, tattoos or other blemishes on or near the skin test site, which affect the test results; 10. Those who have received photorejuvenation, laser and other medical aesthetic treatments or other facial beauty methods that may affect the skin condition in the past three months; 11. Those who have participated in similar facial tests, oral drug trials or other clinical trials in the past 2 months; 12. Those with highly sensitive constitution, known allergies to cosmetics or daily chemical ingredients, alcohol, rubber or drugs; 13. Those who need to be exposed to outdoor sunlight for a long time due to work or other reasons; 14. Those who have other iatrogenic problems that may affect the test results (such as coagulation dysfunction, severe hyperglycemia, hypertension, hyperlipidemia, mental illness or other major diseases; 15. Those who are not suitable for the trial according to other clinical assessments; 16. Non-volunteer participants or those who cannot complete the prescribed test content as required.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| skin firmness; | — |
Secondary
| Measure | Time frame |
|---|---|
| angle of the eye corner;Ocular wrinkle count;Ocular wrinkle surface area;pouch volume;skin roughness around the eyes;water content of the stratum corneum of the skin;Ocular wrinkle volume;skin melanin; | — |
Countries
China
Contacts
Public ContactYe Li
Dematology Hospital of Southern Medical University
Outcome results
None listed